Additional/Other Research

Taking research from the lab to the patient


STAMPEDE2 has several pre-specified and exploratory sub-studies, involving a subset of participants from the main trial who consent to take part. The goal of these sub-studies is to help improve tools for diagnosing prostate cancer, as well as predicting how the disease is likely to develop. They will also improve our understanding of what makes treatment more or less effective.

 

BLOOD
  • Assessing if a treatment is working
    Aim: To find out if measuring the levels of PSA and genetic material (DNA) from the tumour found in the blood after starting treatment can give us information about how well patients in Comparison P do in the long term.
  • Understanding why treatments stop working
    Aim: To use signals in the blood, such as genetic material (DNA), to help us understand why treatment stops working.
TUMOUR
  • How tumour genetics can affect outcomes
    Aim: To look at whether the genetic makeup of the tumour can predict how well patients do on treatment.
  • Examining genetic changes in the tumour
    Aim: To analyse genetic changes in tumours and see if these can tell us about how well patients will do on treatment.
OTHER
  • Classifying tumours using artificial intelligence (AI)
    Aim: To see if we can use AI to group tumour samples according to specific characteristics and use this to predict how well patients do on treatment.
  • Using imaging to categorise the extent of cancer spread
    Aim: To use X-ray or MRI imaging to categorise patients according to how far the cancer has spread, and to confirm if this is associated with how well patients do in the long term.
  • Using imaging to assess side effects from treatment
    Aim: To use X-ray or MRI imaging to assess treatment side effects affecting bone and muscle.

For more information related to prostate cancer research, please see the following website links below:

Prostate Cancer UK - Research We Fund

ZERO Prostate Cancer - Biomarkers & Genomic Testing

Treatment Resistance Group - Research Overview